Premium
Pd‐Catalyzed Reductive Cyclization of Nitroarenes with CO 2 as the CO Source
Author(s) -
Guan Xinyu,
Zhu Haoran,
Zhao Yingwei,
Driver Tom G.
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201901629
Subject(s) - chemistry , reductive amination , steric effects , catalysis , reductive elimination , combinatorial chemistry , organic chemistry , amination , medicinal chemistry
A reductive amination process that constructs indoles, carbazoles or benzimidazoles from nitroarenes – irrespective of their electronic or steric nature – was developed that uses CO 2 as the source of CO. The process is robust, tolerating common gaseous components of flue gas (H 2 S, SO 2 , NO and H 2 O) without adversely affecting the reductive cyclization.