Premium
Imidazo‐Fused Isoindoles by Pd(II)/Ag(I)‐Promoted Intramolecular Dehydrogenative Coupling
Author(s) -
Lessi Marco,
Lucci Antonio,
Cuzzola Angela,
Bellina Fabio
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201901618
Subject(s) - intramolecular force , chemistry , hydrogen bond , combinatorial chemistry , carbon atom , medicinal chemistry , photochemistry , stereochemistry , molecule , organic chemistry , ring (chemistry)
An effective Pd(II)/Ag(I)‐promoted intramolecular cross‐dehydrogenative coupling (CDC) of substituted 1‐benzylimidazoles under air provides, for the first time, a simple access to several functionalized imidazo[2,1 ‐a ]isoindoles, an interesting class of polycyclic heteroaromatic compounds. The direct involvement of two unactivated carbon–hydrogen bonds, without any directing group, grants an elevated atom economy of the whole process.