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Reductions of Imines Using Zirconocene Chloride Hydride
Author(s) -
Vargová Denisa,
Mudráková Brigita,
Némethová Ivana,
Šebesta Radovan
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201901607
Subject(s) - chemistry , aldimine , imine , hydride , chloride , organic chemistry , aqueous solution , filtration (mathematics) , combinatorial chemistry , catalysis , metal , statistics , mathematics
Herein, we describe the fast, chemoselective, and clean reduction of imines with zirconocene chloride hydride. The reaction works well on aromatic and enolizable aliphatic aldimines, as well as ketimines. A range of N ‐protecting groups and various functional groups were tolerated in the imine structure. The corresponding amines were obtained in high yields (65 % – quantitative) in short reaction times, and often, no purification was required other than standard aqueous workup and a short filtration.
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