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Hemoglobin‐Catalyzed Synthesis of Indolizines Under Mild Conditions
Author(s) -
Li Fengxi,
Tang Xuyong,
Xu Yaning,
Wang Chunyu,
Zhang Liu,
Zhang Jiaxin,
Liu Jiaxu,
Li Zhengqiang,
Wang Lei
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201901591
Subject(s) - chemistry , catalysis , scope (computer science) , combinatorial chemistry , substrate (aquarium) , hemoglobin , biocatalysis , organic chemistry , organic synthesis , reaction conditions , reaction mechanism , oceanography , computer science , programming language , geology
Hemoglobin‐catalyzed synthesis of indolizines via a multicomponent reaction has been reported for the first time. The corresponding indolizines were obtained in moderate to high yields by using this method. This mild, efficient and practical method is distinguished by the use of a commercially inexpensive biocatalyst and readily available starting materials, wide substrate scope, and operational simplicity. Furthermore, this method expands the application of hemoglobin in organic synthesis.