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Front Cover: Biotransformations in Pure Organic Medium: Organic Solvent‐Labile Enzymes in the Batch and Flow Synthesis of Nitriles (Eur. J. Org. Chem. 41/2019)
Author(s) -
Hinzmann Alessa,
Adebar Niklas,
Betke Tobias,
Leppin Monja,
Gröger Harald
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201901543
Subject(s) - chemistry , organic synthesis , catalysis , solvent , organic solvent , flow chemistry , biocatalysis , front cover , organic chemistry , enzyme catalysis , enzyme , combinatorial chemistry , chemical engineering , cover (algebra) , reaction mechanism , mechanical engineering , engineering
The Front Cover shows a biocatalytic process running in pure organic medium in which an enzyme being labile towards this organic solvent is used. The process concept being suitable for flow and batch mode is based on encapsulation of the enzyme as a whole cell catalyst in a superabsorber as a “solid aqueous phase” in combination with an organic solvent with a high logP value as “mobile phase”. This approach was exemplified for a biocatalytic synthesis of n ‐octanenitrile, leading to >99% conversion. In contrast, very low or no conversion were observed when applying other methods such as the direct use of whole cell catalysts in pure organic medium or biphasic solvent mixtures. More information can be found in the Communication by H. Gröger et al.