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New Strategy for the Synthesis of Heterocycles via Copper‐Catalyzed Oxidative Decarboxylative Amination of Glyoxylic Acid
Author(s) -
Niu Bin,
Li Shaoqing,
Cui Chang,
Yan Yizhe,
Tang Lin,
Wang Jianyong
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201901538
Subject(s) - glyoxylic acid , chemistry , synthon , amination , catalysis , organic chemistry , reductive amination , copper , combinatorial chemistry
A copper‐catalyzed oxidative decarboxylative amination of glyoxylic acid with substrates having two nitrogen‐nucleophilic sites was first demonstrated. Using this novel approach, 1,3,5‐triazines, quinazolinones and quinazolines were obtained in up to 93 % yields. Notably, glyoxylic acid was employed as the C1 synthon for heterocycles. This strategy enriches the application of glyoxylic acid for the synthesis of valuable heterocycles.