New Strategy for the Synthesis of Heterocycles via Copper‐Catalyzed Oxidative Decarboxylative Amination of Glyoxylic Acid | Zendy

Niu Bin | Zendy; Li Shaoqing | Zendy; Cui Chang | Zendy; Yan Yizhe | Zendy; Tang Lin | Zendy; Wang Jianyong | Zendy

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New Strategy for the Synthesis of Heterocycles via Copper‐Catalyzed Oxidative Decarboxylative Amination of Glyoxylic Acid

Author(s) -

Niu Bin,

Li Shaoqing,

Cui Chang,

Yan Yizhe,

Tang Lin,

Wang Jianyong

Publication year - 2019

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201901538

Subject(s) - glyoxylic acid , chemistry , synthon , amination , catalysis , organic chemistry , reductive amination , copper , combinatorial chemistry

A copper‐catalyzed oxidative decarboxylative amination of glyoxylic acid with substrates having two nitrogen‐nucleophilic sites was first demonstrated. Using this novel approach, 1,3,5‐triazines, quinazolinones and quinazolines were obtained in up to 93 % yields. Notably, glyoxylic acid was employed as the C1 synthon for heterocycles. This strategy enriches the application of glyoxylic acid for the synthesis of valuable heterocycles.

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