Diastereoselective Synthesis of 2,6‐Disubstituted‐1,2,3,6‐Tetrahydropyridines through a Palladium‐Catalyzed Intramolecular Allylic Amination | Zendy

Visseq Alexia | Zendy; Boibessot Thibaut | Zendy; Nauton Lionel | Zendy; Théry Vincent | Zendy; Anizon Fabrice | Zendy; AbrunhosaThomas Isabelle | Zendy

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Diastereoselective Synthesis of 2,6‐Disubstituted‐1,2,3,6‐Tetrahydropyridines through a Palladium‐Catalyzed Intramolecular Allylic Amination

Author(s) -

Visseq Alexia,

Boibessot Thibaut,

Nauton Lionel,

Théry Vincent,

Anizon Fabrice,

AbrunhosaThomas Isabelle

Publication year - 2019

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201901520

Subject(s) - amination , intramolecular force , allylic rearrangement , palladium , catalysis , chemistry , medicinal chemistry , combinatorial chemistry , organic chemistry

An efficient synthesis of 2,6‐disubstituted‐1,2,3,6‐tetrahydropyridines is reported, featuring a highly diastereoselective palladium‐catalyzed intramolecular allylic amination from non‐activated alcohols. This method allowed a straightforward access to 2,6‐ trans ‐1,2,3,6‐tetrahydropyridines with de up to 100 % under mild conditions, in moderate to good yields.

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