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Rh(III)‐Catalyzed Direct Amination of Aromatic Ketoximes Enabled by Potassium Acetate
Author(s) -
Liu Lingling,
Wang Ning,
Dai Chenyang,
Han Yi,
Yang Shan,
Huang Zhibin,
Zhao Yingsheng
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201901517
Subject(s) - chemistry , amination , rhodium , intermolecular force , aryl , catalysis , potassium , organic chemistry , medicinal chemistry , combinatorial chemistry , molecule , alkyl
A method to achieve rhodium(III)‐catalyzed, potassium acetate enabled intermolecular C–H amination of ketoximes using various benzenesulfonamide, especially 4‐nitrobenzenesulfonamide is reported. Various aryl ketoximes substituted with electron‐withdrawing functional groups were all well tolerated and produced the corresponding products in moderate to good yields. A preliminary mechanistic study revealed that potassium acetate is essential to realizing intermolecular amination.