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Oxidative Annulation of 3‐Aryl‐2 H ‐benzo[e][1,2,4]thiadiazine‐1,1‐dioxides with Aryl Aldehydes: An Easy Access to Hydroxyisoindolo[1,2‐ b ] benzothiadiazinedioxide Scaffolds
Author(s) -
Kumar G. Ravi,
Banik Swarnayu,
Ramesh Boora,
Sridhar Balasubramanian,
Venkata Subba Reddy Basireddy
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201901509
Subject(s) - chemistry , annulation , intramolecular force , aryl , toluene , oxidative phosphorylation , combinatorial chemistry , medicinal chemistry , stereochemistry , organic chemistry , catalysis , biochemistry , alkyl
A novel and efficient approach has been developed for the synthesis of a diverse range of hydroxyisoindolo[1,2‐ b ]benzothiadiazinedioxide derivatives through a sequential palladium catalyzed cross‐dehydrogenative coupling (CDC) and intramolecular cyclization. This method works not only with aryl aldehydes and alcohols but also with toluene to generate angularly fused heterocycles in good to excellent yields.