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Decarboxylative C–C and C–N Bond Formation by Ligand‐Accelerated Iron Photocatalysis
Author(s) -
Feng Guangshou,
Wang Xiaofei,
Jin Jian
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201901381
Subject(s) - chemistry , decarboxylation , photocatalysis , iridium , photochemistry , ruthenium , radical , adduct , ligand (biochemistry) , oxidative decarboxylation , alkyl , amine gas treating , irradiation , medicinal chemistry , catalysis , organic chemistry , biochemistry , receptor , physics , nuclear physics
The photoexcited state lifetimes of iron complexes are typically much shorter than those of iridium and ruthenium complexes. For that reason, iron complexes find less application in photochemical organic synthesis. Through iron photocatalysis, a mild and effective protocol for decarboxylative C–C and C–N bond formation has been achieved. The carboxylic acids readily undergo radical decarboxylation in the presence of Fe 2 (SO 4 ) 3 and di‐(2‐picolyl)amine under visible light irradiation. The resulting alkyl radicals then react with Michael acceptors or azodicarboxylates to furnish the adducts.