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Nickel Catalyzed Intermolecular Carbonyl Addition of Aryl Halide
Author(s) -
Ishida Seima,
Suzuki Hiroyuki,
Uchida Seiichiro,
Yamaguchi Eiji,
Itoh Akichika
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201901367
Subject(s) - chemistry , aryl , halide , aldehyde , nickel , catalysis , intermolecular force , organic chemistry , enantioselective synthesis , aryl halide , combinatorial chemistry , alkyl , molecule
In this study, we develop a nickel‐catalyzed carbonyl arylation reaction employing aldehydes with aryl and allyl halides. Various aryl, α,β‐unsaturated aldehyde and aliphatic aldehydes can be converted into their corresponding secondary alcohols in moderate‐to‐high yields. In addition, we extended this approach to develop an asymmetric reductive coupling reaction that combines nickel salts with chiral bisoxazoline ligands to give secondary alcohols with moderate enantioselectivity.