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Metal and Solvent‐Free Synthesis of 2 H ‐Pyrido[1,2‐ a ]pyrimidin‐2‐ones Catalyzed by Elemental Sulfur
Author(s) -
Pavithra Thangavel,
Devi E. Sankari,
Nagarajan Subbiah,
Sridharan Vellaisamy,
Maheswari C. Uma
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201901356
Subject(s) - chemistry , aminopyridines , catalysis , sulfur , organic chemistry , solvent , reaction conditions , combinatorial chemistry , metal
The efficiency of elemental sulfur for the synthesis of 2 H ‐pyrido[1,2‐ a ]pyrimidin‐2‐ones has been demonstrated. This strategy involves coupling of 2‐aminopyridines and β‐oxo esters under neat condition in the absence of external oxidant. The reaction does not require pre‐functionalization of the substrates, thus making it an alternate approach for the synthesis of 2 H ‐pyrido[1,2‐ a ]pyrimidin‐2‐ones. The reaction was tolerant to several substituted 2‐aminopyridines and β‐oxo esters.