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Tf 2 O‐Mediated Intermolecular Coupling of Secondary Amides with Enamines or Ketones: A Versatile and Direct Access to β‐Enaminones
Author(s) -
Liu YongPeng,
Zhu ChengJie,
Yu CunCun,
Wang AiE,
Huang PeiQiang
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201901354
Subject(s) - chemistry , intermolecular force , molecular sieve , functional group , combinatorial chemistry , condensation , ketone , condensation reaction , coupling (piping) , organic chemistry , computational chemistry , catalysis , molecule , polymer , mechanical engineering , engineering , physics , thermodynamics
Based on the Tf 2 O‐mediated intermolecular reaction of secondary amides with enamines derived from ketones, a novel approach to β‐enaminones has been developed. The reaction is widely functional group tolerant and highly chemoselective. In the presence of 4 Å molecular sieves, the method can be extended to the one‐pot condensation of secondary amides with ketones for NH β‐enaminones synthesis.