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Au‐Catalyzed Stereoselective Ritter Reaction of Haloalkynes with Nitriles for ( Z )‐ β ‐Halogenated Enamides
Author(s) -
Liu Congrong,
Yang Fulai
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201901318
Subject(s) - ritter reaction , chemistry , stereoselectivity , catalysis , organic chemistry , medicinal chemistry
An efficient and stereoselective protocol has been developed for the synthesis of ( Z )‐ β ‐halogenated enamide through gold catalyzed Ritter reaction. In the presence of 2 mol% BrettPhosAuCl and 2 mol% AgNTf 2 , a broad range of nitriles smoothly underwent Ritter reaction with aromatic, vinylic or aliphatic haloalkynes to give structurally diverse ( Z )‐ β ‐halogenated enamides in excellent to good yields.
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