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Direct Arylations via C–H Bond Functionalization of 1,2,3‐Triazoles by a Reusable Pd/C Catalyst Under Solvent‐Free Conditions
Author(s) -
Punzi Angela,
Zappimbulso Nicola,
Farinola Gianluca M.
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201901305
Subject(s) - chemistry , anhydrous , catalysis , surface modification , aryl , solvent , click chemistry , combinatorial chemistry , green chemistry , triazole , organic chemistry , reaction mechanism , alkyl
Fully substituted triazoles are synthesized by a sustainable direct arylation reaction performed under solvent‐free conditions and in the presence of a recyclable Pd/C heterogeneous catalyst. Exclusion of air as well as anhydrous conditions are not required, enabling a convenient synthesis of 1,4,5‐trisubstituted 1,2,3‐triazoles and 1,2,3‐triazole‐fused isoindolines starting from 1,4‐disubstituted 1,2,3‐triazoles, easily prepared via click chemistry, and functionalized aryl iodides.