Palladium‐Catalyzed Synthesis of Symmetrical and Unsymmetrical Ureas Using Chromium Hexacarbonyl as a Convenient and Safe Alternative Carbonyl Source | Zendy

Mozaffari Mozhdeh | Zendy; Nowrouzi Najmeh | Zendy

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Palladium‐Catalyzed Synthesis of Symmetrical and Unsymmetrical Ureas Using Chromium Hexacarbonyl as a Convenient and Safe Alternative Carbonyl Source

Author(s) -

Mozaffari Mozhdeh,

Nowrouzi Najmeh

Publication year - 2019

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201901273

Subject(s) - chemistry , sodium azide , carbonylation , palladium , curtius rearrangement , aryl , catalysis , chromium , nucleophile , organic chemistry , urea , combinatorial chemistry , azide , carbon monoxide , alkyl

Pd‐catalyzed synthesis of urea derivatives from aryl iodides and different aliphatic and aromatic amines using sodium azide and chromium hexacarbonyl is described. In this process, carbonylation of aryl iodides, Curtius rearrangement of aroyl azides, and nucleophilic addition of amines sequentially occur to afford the products in good to excellent yields. This protocol is operationally simple and displays a broad substrates scope.

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