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A Catalyst‐Free Minisci‐Type Reaction: the C–H Alkylation of Quinoxalinones with Sodium Alkylsulfinates and Phenyliodine(III) Dicarboxylates
Author(s) -
Wang Liping,
Zhao Jiquan,
Sun Yuting,
Zhang HongYu,
Zhang Yuecheng
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201901266
Subject(s) - chemistry , alkylation , catalysis , sodium , medicinal chemistry , organic chemistry , combinatorial chemistry
A direct C–H alkylation of quinoxalinones at the C‐3 position with sodium alkylsulfinates and phenyliodine(III) dicarboxylates has been developed under catalyst‐free conditions. A series of 3‐alkylquinoxalinones were afforded in moderate to excellent yields in this protocol, which offers a practical and efficient access to biologically interesting 3‐alkylquinoxalin‐2(1 H )‐one derivatives.