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Recent Progress in the Synthesis of Naturally Occurring Siderophores
Author(s) -
GarzónPosse Fabián,
QuevedoAcosta Yovanny,
MahechaMahecha Camilo,
AcostaGuzmán Paola
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201901257
Subject(s) - siderophore , chemistry , bioavailability , microorganism , environmental chemistry , aqueous medium , ferric , bacteria , nanotechnology , aqueous solution , biochemistry , biology , organic chemistry , materials science , gene , bioinformatics , genetics
Iron is an indispensable element for the development of almost all living things, and its acquisition is a key process for organisms. However, the low solubility of Fe 3+ in aqueous systems causes its reduced bioavailability. Thus, organisms confronted with low iron availability have developed several iron scavenging strategies, and one of these ways is to use low molecular‐weight organic molecules, which are specific ferric ion chelators called siderophores. These compounds exhibit an extremely high affinity and specificity for Fe 3+ and are produced and secreted by bacteria, fungi, and plants. Recently, siderophores have attracted much attention due to their applications in areas such as microbial ecology, specific crop production, detoxification of heavy metal‐contaminated samples, biodetection of metals, and the selective delivery of antibiotics to resistant bacterial strains. Nevertheless, the limited supply of these natural products has been an obstacle that needs to be overcome. This review provides an overview of the contemporary developments in the total synthesis of naturally occurring siderophores during the last two decades.