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Metal‐Free Visible‐Light‐Mediated Hydrotrifluoromethylation of Unactivated Alkenes and Alkynes in Continuous Flow
Author(s) -
Barthelemy AnneLaure,
Dagousset Guillaume,
Magnier Emmanuel
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201901252
Subject(s) - chemistry , radical , continuous flow , flow chemistry , metal , photoredox catalysis , photochemistry , transition metal , catalysis , combinatorial chemistry , organic chemistry , photocatalysis , physics , mechanics
We report herein a novel photoredox‐catalyzed hydrotrifluoromethylation of unsaturated systems under continuous flow. This metal‐free method is easily broadened to other perfluoroalkyl groups (R F = CF 3 , CFCl 2 , CF 2 Br, C 4 F 9 ) thanks to the use of sulfilimino iminiums as sources of · R F radicals. The mild reaction conditions are compatible with unactivated alkenes bearing a wide range of functionalities, as well as with alkynes for the first time.