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Enantioselective γ‐Alkylation of α,β‐Unsaturated Aldehydes Using New Cinchona‐Based Primary Amine Catalyst
Author(s) -
Huang YongShuang,
Song ShuangGui,
Ren Lei,
Li YouGui,
Wu Xiang
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201901219
Subject(s) - chemistry , cinchona , alkylation , enantioselective synthesis , catalysis , organic chemistry , amine gas treating , acetic acid , primary (astronomy) , methanol , organocatalysis , physics , astronomy
New cinchona‐based primary amine catalysts were prepared and screened as organocatalysts for the γ‐alkylation of α,β‐unsaturated aldehydes with bis(4‐dimethylaminophenyl)methanol. Catalyst C3 containing acetic acid group yielded γ‐alkylated products in good yields (up to 94 %) with up to 90 % ee . This new primary aminocatalyst provide new opportunities to explore novel asymmetric transformations.