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Nickel‐Catalyzed Ortho C–H Methylation of Aromatic Amides with Di‐ tert ‐butyl Peroxide as Methylation Reagent
Author(s) -
Liu Da,
Yu Lin,
Yu Yongqi,
Xia Zhen,
Song Zenan,
Liao Lihong,
Tan Ze,
Chen Xiang
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201901211
Subject(s) - chemistry , reagent , catalysis , methylation , acetone , nickel , hydrogen peroxide , combinatorial chemistry , ligand (biochemistry) , peroxide , medicinal chemistry , organic chemistry , biochemistry , receptor , gene
A new efficient protocol for the ortho ‐methylation of benzamides with DTBP has been developed via Ni(II)‐catalyzed C–H activation directed by 8‐aminoquinoline. This method is performed under base‐free, ligand‐free conditions and utilizes cheap and commercially available reagents. Moreover, the by‐product acetone derived from DTBP does not affect the purification of the product.