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Phosphine‐Catalyzed β‐Selective Conjugate Addition of α‐Fluoro‐β‐ketoamides to Allenic Esters
Author(s) -
Vaishanv Narendra Kumar,
Zaheer Mohd Khalid,
Kant Ruchir,
Mohanan Kishor
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201901199
Subject(s) - chemistry , conjugate , phosphine , catalysis , substrate (aquarium) , selectivity , organic chemistry , combinatorial chemistry , mathematical analysis , oceanography , mathematics , geology
A Strategy for the β‐selective conjugate addition of α‐fluoro‐β‐ketoamides to allenic esters has been developed via phosphine catalysis. This protocol exhibits a broad substrate scope, and a wide range of compounds bearing fluorinated quaternary carbon center was obtained in good to excellent yields. This protocol allows the use of γ‐substituted allenic esters to furnish the products with exclusive β‐selectivity.