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Isocyanide‐Based Multicomponent Reactions of Free Phenylboronic Acids
Author(s) -
Neochoritis Constantinos G.,
ZarganesTzitzikas Tryfon,
Novotná Michaela,
Mitríková Tatiana,
Wang Zefeng,
Kurpiewska Katarzyna,
KalinowskaTłuścik Justyna,
Dömling Alexander
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201901187
Subject(s) - chemistry , isocyanide , phenylboronic acid , combinatorial chemistry , primary (astronomy) , suzuki reaction , organic chemistry , catalysis , palladium , physics , astronomy
Boronic acids are amongst the most useful synthetic intermediates, frequently used by modern drug design. However, their access and fast synthesis of libraries are often problematic. We present a methodology on the synthesis of drug‐like scaffolds via IMCRs with unprotected phenylboronic acids. To demonstrate an application of our approach, we also performed one‐pot Suzuki couplings on the primary MCR scaffolds. Moreover, we performed a thorough data‐mining of the Cambridge Structural Database, revealing interesting geometrical features.