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Synthesis of 5‐[(Pentafluorosulfanyl)methyl]‐γ‐butyrolactones via a Silver‐Promoted Intramolecular Cyclization Reaction
Author(s) -
Roudias Majdouline,
Gilbert Audrey,
Paquin JeanFrançois
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201901163
Subject(s) - chemistry , intramolecular force , yield (engineering) , medicinal chemistry , intramolecular reaction , stereochemistry , materials science , metallurgy
The synthesis of 5‐[(pentafluorosulfanyl)methyl]‐γ‐butyrolactones bearing different substituents at position 3 or 4 is reported. A silver‐promoted intramolecular cyclization of substituted 4‐chloro‐5‐(pentafluorosulfanyl)pentanoic acids allows the preparation of the substituted SF 5 ‐containing γ‐butyrolactones in up to 96 % yield.
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