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Uncovering the Mechanism Leading to the Synthesis of Symmetric and Asymmetric Tröger′s Bases
Author(s) -
Lanza Priscila A.,
Dusso Diego,
Ramirez Cristina L.,
Parise Alejandro R.,
Chesta Carlos A.,
Moyano E. Laura,
Vera D. Mariano A.
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201901141
Subject(s) - chemistry , supramolecular chemistry , carbocation , enantioselective synthesis , mechanism (biology) , kinetic resolution , combinatorial chemistry , computational chemistry , reaction mechanism , stereochemistry , nanotechnology , molecule , catalysis , organic chemistry , philosophy , epistemology , materials science
Tröger′s bases have been attracting great interest due to their potential applications in nanoelectronics, supramolecular chemistry, molecular recognition, biological activity and auxiliaries for asymmetric synthesis. However, there is still no detailed step by step proposal for the mechanism leading to the production of these compounds available. A set of five model syntheses of symmetric and asymmetric Tröger′s base derivatives starting from substituted anilines and formaldehyde was studied and envisaged as representative for understanding the underlying mechanism. All reasonable pathways were thoroughly scanned by means of DFT calculations. The highest energy TS was associated with the entrance of the first formaldehyde which produces the first out of three key carbocations. The last step, the closure of the methylene‐bridged diazocyne heterocycle was also found of kinetic relevance and as a source of stable intermediates or by‐products. The whole mechanistic picture would provide keys for the rational planning of the synthesis of these compounds.