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Construction of α‐(Hetero)aryl Ethenesulfonyl Fluorides for SuFEx Click Chemistry
Author(s) -
Leng Jing,
Alharbi Njud S.,
Qin HuaLi
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201901106
Subject(s) - chemistry , aryl , click chemistry , electrophile , fluoride , suzuki reaction , sulfonyl , combinatorial chemistry , organic chemistry , catalysis , inorganic chemistry , alkyl
The construction of α‐(hetero)aryl ethenesulfonyl fluorides was achieved via a Pd‐catalyzed Suzuki coupling of arylboronic acids with 1‐bromoethene‐1‐sulfonyl fluoride (1‐Br‐ESF). The novel α‐aryl ethenesulfonyl fluorides were found to be another selectively addressable bis ‐electrophile for wide diversification through SuFEx click chemistry, or Michael addition with excellent chemical discrimination.