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Zn‐Catalyzed [3+2]‐Annulation Strategy: Straightforward Access to Aminoalkyl Indolizines
Author(s) -
Li Junxuan,
Yang Daji,
Wang Hua,
Zhu Baofu,
Cao Hua
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201901102
Subject(s) - annulation , chemistry , catalysis , atom economy , combinatorial chemistry , domino , enantioselective synthesis , organocatalysis , cascade reaction , reaction conditions , organic chemistry
An efficient Zn‐catalyzed [3+2]‐annulation strategy for the synthesis of aminoalkyl indolizines has been developed. The three‐component domino reaction of 2‐(pyridin‐2‐yl)acetates, ynals and amines proceeds smoothly with high efficiency to afford the indolizines in good yields. This transformation may facilitate the development of new synthetic methods for the efficient and sustainable construction of aminoalkyl indolizines in an atom‐economic way from simple, abundant starting materials.