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Cover Feature: Tandem Chiral Cu(II) Phosphate‐Catalyzed Deoxygenation of Nitrones/Enantioselective Povarov Reaction with Enecarbamates (Eur. J. Org. Chem. 31‐32/2019)
Author(s) -
Gelis Coralie,
Levitre Guillaume,
Guérineau Vincent,
Touboul David,
Neuville Luc,
Masson Géraldine
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201901089
Subject(s) - deoxygenation , chemistry , stereocenter , enantioselective synthesis , catalysis , combinatorial chemistry , organocatalysis , tandem , phosphoric acid , copper , imine , organic chemistry , medicinal chemistry , materials science , composite material
The Cover Feature shows the tandem deoxygenation–Povarov reaction of nitrones with enecarbamates catalyzed by a chiral copper‐diphosphate complex. Under the conditions, the catalyst is able to perform an “enlightening” rapid deoxygenation and subsequently assembles the resulting imine and the enecarbamates to form 4‐amino‐tetrahydroquinolines with high control of the three stereocenters. This complex is easily formed starting from readily available copper (II) and chiral phosphoric acid. More information can be found in the Communication by G. Masson et al.