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Cover Feature: Binding and Beyond: What Else Can G‐Quadruplex Ligands Do? (Eur. J. Org. Chem. 31‐32/2019)
Author(s) -
O'Hagan Michael P.,
Morales Juan C.,
Galan M. Carmen
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201901088
Subject(s) - cover (algebra) , chemistry , nucleic acid , feature (linguistics) , g quadruplex , molecule , small molecule , stereochemistry , biochemistry , organic chemistry , dna , philosophy , mechanical engineering , linguistics , engineering
The Cover Feature shows examples of small molecules that unfold G‐quadruplex (G4) nucleic acid structures. Hundreds of ligands bind G4 with high specificity and affinity, an adventure through the universe of these chemotypes discover molecules that can do more than simply associate with G4 in a host–guest fashion. Small molecules can induce G4 conformational switching, selective covalent modification, and even allow the stimuli‐responsive control of these fascinating architectures. The Cover Feature nucleic acid cartoons were kindly provided by S. Haldar and A.J. Mulholland. More information can be found in the Minireview by M. P. O'Hagan, M. C. Galan et al.