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Cover Feature: Catalytic Enantioselective Synthesis of Bicyclic Lactam N , S ‐Acetals in One Pot by Cascade Transformations (Eur. J. Org. Chem. 29/2019)
Author(s) -
Zhang Kaiheng,
Deiana Luca,
Grape Erik Svensson,
Inge A. Ken,
Córdova Armando
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201901084
Subject(s) - bicyclic molecule , enantioselective synthesis , chemistry , lactam , cascade , stereochemistry , stereoselectivity , catalysis , combinatorial chemistry , organic chemistry , chromatography
The Cover Feature shows a versatile strategy for the enantioselective synthesis of bicyclic lactam N , S ‐acetals by one‐pot cascade transformations. The transformations between readily available substrates is promoted by chiral amines and creates bicyclic or tricyclic lactam N , S ‐acetals with high chemo‐ and stereoselectivity (up to >99.5:0.5 d.r. and >99% ee ) in one‐pot operations More information can be found in the Full Paper by A. Córdova et al.