Premium
Carbonylative Negishi‐Type Coupling of 2‐Iodoglycals with Alkyl and Aryl Halides
Author(s) -
Esteves Henrique A.,
Darbem Mariana P.,
Pimenta Daniel C.,
Stefani Hélio A.
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201901081
Subject(s) - chemistry , negishi coupling , alkyl , aryl , halide , organic chemistry , combinatorial chemistry , catalysis
C ‐Glycosides are valuable organic compounds in the field of medicinal chemistry due to their ubiquity inside living systems and pronounced biological activity. Herein, we describe an approach to alkyl‐ketones bearing glycal units via the Pd‐catalyzed carbonylative coupling of 2‐iodoglycals and alkyl and aryl halides. Examples bearing a variety of functional groups are presented as well as a mechanistic proposal for this transformation.