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Synthesis and Anticancer Activity of Structure Simplified Naturally Inspired Dimeric Chromenone Derivatives
Author(s) -
Ali Rameez,
Guan Yong,
Leveille Alexandria N.,
Vaughn Elizabeth,
Parelkar Sangram,
Thompson Paul R.,
Mattson Anita E.
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201901026
Subject(s) - chemistry , stereocenter , cytotoxicity , combinatorial chemistry , hl60 , cancer cell lines , stereochemistry , leukemia , cell culture , anticancer drug , cancer cell , biochemistry , drug , cell , in vitro , cancer , pharmacology , immunology , enantioselective synthesis , genetics , medicine , biology , catalysis
Select dimeric chromenones exhibit low micromolar cytotoxicity toward lymphoma and leukemia cell lines, L5178Y and HL60, respectively. The bioactive dimeric chromenones were identified from a focused library of structurally simplified derivatives of naturally occurring dimeric chromenones and tetrahydroxanthones that was prepared as part of this study. The simple dimeric chromenone scaffolds contain no stereogenic centers, are easily synthesized, and may be utilized as lead compounds in cancer research and drug discovery.