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sp 2‐C–H Acetoxylation of Diversely Substituted ( E )‐1‐(Arylmethylene)‐2‐phenylhydrazines Using PhI(OAc) 2 as Acetoxy Source at Ambient Conditions
Author(s) -
Brahmachari Goutam,
Karmakar Indrajit
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201900994
Subject(s) - chemistry , aldehyde , regioselectivity , combinatorial chemistry , functional group , catalysis , organic chemistry , medicinal chemistry , polymer
A catalyst‐ and additive‐free simple and straightforward method for regioselective direct sp 2 C–H acetoxylation reaction of aldehyde hydrazones has been achieved at ambient temperature employing PIDA as an acetoxy source. The scope of the reaction has been successfully verified with a wide range of biologically important aldehyde hydrazones with diverse functional group tolerance. The method is highly selective, mild and efficient, operationally simple, rapid and high‐yielding.