Spirobicyclic and Tetracyclic Pyrazolidinones: Syntheses and Properties | Zendy

Perez Fabien | Zendy; Leveille Thibault | Zendy; Bertolotti Mathilde | Zendy; Rodriguez Jean | Zendy; Coquerel Yoann | Zendy

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Spirobicyclic and Tetracyclic Pyrazolidinones: Syntheses and Properties

Author(s) -

Perez Fabien,

Leveille Thibault,

Bertolotti Mathilde,

Rodriguez Jean,

Coquerel Yoann

Publication year - 2019

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201900989

Subject(s) - enantiopure drug , annulation , stereoselectivity , cycloaddition , iminium , chemistry , molecule , stereochemistry , combinatorial chemistry , organic chemistry , enantioselective synthesis , catalysis

The stereoselective syntheses of spirobicyclic and tetracyclic pyrazolidinones are reported based on a (3+2) annulation between hydrazones and α‐oxoketenes. Some of these conformationally constrained molecules were resolved as enantiopure materials by HPLC techniques and evaluated as aminocatalysts for iminium activation in a model Diels–Alder cycloaddition.

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