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Synthesis of Fluorine‐Containing Molecular Entities Through Fluoride Ring Opening of Oxiranes and Aziridines
Author(s) -
Remete Attila Márió,
Kiss Loránd
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201900981
Subject(s) - regioselectivity , chemistry , fluorine , ring (chemistry) , nucleophile , combinatorial chemistry , cycloalkane , organic chemistry , fluoride , catalysis , inorganic chemistry
The current minireview highlights the most relevant methodologies for the creation of fluorinated scaffolds accessed through transformations of three‐membered heterocycles (oxiranes and aziridines) involving their opening with various nucleophilic fluorinating agents reported over recent years. The purpose of the review is also to provide an overview of the ring‐opening synthetic practices with fluoride towards different functionalized, fluorine‐containing scaffolds with the focus on regioselectivity/regiocontrol and enantioselectivity including symmetric or unsymmetric monoheterocycles, cycloalkane‐fused oxiranes and aziridines.