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Asymmetric Organocatalytic Conjugate Addition of Electron‐Rich Phenols and 1,3‐Dicarbonyls to Arylsulfonyl Indoles in an Oil‐Water Biphasic System
Author(s) -
Han JengLiang,
Liao YuTing,
Chang ChiaHao
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201900962
Subject(s) - chemistry , conjugate , bifunctional , organocatalysis , phenols , yield (engineering) , stereoselectivity , catalysis , enantioselective synthesis , organic chemistry , medicinal chemistry , mathematical analysis , materials science , mathematics , metallurgy
The asymmetric conjugate addition of electron‐rich phenols and 1,3‐dicarbonyls with arylsulfonyl indoles catalyzed by bifunctional organocatalysts has been established. The chiral 3,3‐disubstituted oxindoles derivatives were obtained in good to high yields (up to 99 % yield) with high enantioselectivies (up to 98 % ee ). This study showed that the oil‐water biphasic system contributed to the high efficiency and stereoselectivity.