Palladium‐Catalyzed Olefination of 4H‐Benzo[d][1,3]oxazin‐4‐one Derivatives with Activated Alkenes via Preferential Cyclic Imine‐N‐Directed Aryl C‐H Activation | Zendy

Panja Subir | Zendy; Maity Srabani | Zendy; Majhi Biju | Zendy; Ranu Brindaban C. | Zendy

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Palladium‐Catalyzed Olefination of 4H‐Benzo[d][1,3]oxazin‐4‐one Derivatives with Activated Alkenes via Preferential Cyclic Imine‐N‐Directed Aryl C‐H Activation

Author(s) -

Panja Subir,

Maity Srabani,

Majhi Biju,

Ranu Brindaban C.

Publication year - 2019

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201900935

Subject(s) - chemistry , palladium , imine , catalysis , aryl , chelation , selectivity , combinatorial chemistry , medicinal chemistry , stereochemistry , organic chemistry , alkyl

A palladium‐catalyzed chelation‐assisted selective ortho C‐H bond olefination of biologically active 4H‐benzo[ d ][1,3] oxazin‐4‐one derivatives with activated olefins has been achieved. The products are obtained in good yields with high regio‐ and stereoselectivities. This new protocol has been demonstrated to provide a variety of olefinated‐4H‐benzo[d][1,3]oxazin‐4‐one derivatives. The site selectivity of the reaction was explained by a DFT study.

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