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The Cascade Methylation/Cyclization of ortho ‐Cyanoarylacrylamides with Dicumyl Peroxide
Author(s) -
Yang Tao,
Xia WenJin,
Zhou Bin,
Xin Yangchun,
Shen Yuehai,
Li YaMin
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201900918
Subject(s) - chemistry , methylation , reagent , cascade , quinoline , peroxide , combinatorial chemistry , hydrogen peroxide , substrate (aquarium) , transformation (genetics) , scope (computer science) , organic chemistry , chromatography , biochemistry , oceanography , computer science , gene , programming language , geology
A radical cascade methylation/cyclization of ortho ‐cyanoarylacrylamides was developed by utilizing dicumyl peroxide as a methylation reagent. This transformation provides a simple and straightforward approach to methylated quinoline‐2,4(1 H ,3 H )‐diones, and exhibits a wide substrate scope. Furthermore, this reaction could be readily scaled up. A possible mechanism is also proposed.