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Front Cover: N ‐Difluorocyclopropyl‐Substituted Pyrazoles: Synthesis and Reactivity (Eur. J. Org. Chem. 27/2019)
Author(s) -
Nosik Pavel S.,
Poturai Andrii S.,
Pashko Mykola O.,
Melnykov Kostiantyn P.,
Ryabukhin Sergey V.,
Volochnyuk Dmitriy M.,
Grygorenko Oleksandr O.
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201900911
Subject(s) - front cover , chemistry , chemical space , cyclopropane , cover (algebra) , reactivity (psychology) , front (military) , stereochemistry , organic chemistry , combinatorial chemistry , drug discovery , ring (chemistry) , physics , mechanical engineering , medicine , biochemistry , alternative medicine , pathology , engineering , meteorology
The Front Cover shows the “difluoro‐cyclopropanating dragon” (which has been already used to depict the CF 3 SiMe 3 – the NaI system through the series of authors' previous works), who has aimed at new class of substrates, i.e. N ‐vinylazoles, and thus reached a novel area of chemical space occupied by fluorinated cyclopropane derivatives. This method has been used for multigram preparation of all isomeric functionalized N ‐difluorocyclopropylpyrazoles – advanced building blocks for drug discovery. Artwork was partially made by Zorelit studio. More information can be found in the Full Paper by D. M. Volochnyuk, O. O. Grygorenko et al.