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Iron and Phenol Co‐Catalysis for Rapid Synthesis of Nitriles under Mild Conditions
Author(s) -
Meng Hong,
Gao Sen,
Luo Meiming,
Zeng Xiaoming
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201900831
Subject(s) - chemistry , aldehyde , catalysis , oxime , phenol , ligand (biochemistry) , yield (engineering) , substrate (aquarium) , organic chemistry , combinatorial chemistry , biochemistry , materials science , receptor , oceanography , metallurgy , geology
A mild, scalable, high yielding, and rapid route to access diverse nitriles from aldehyde oxime esters enabled by iron(III) and phenol co‐catalysis has been developed. The reaction was performed at room temperature to give nitriles in excellent yield within minutes. Mechanistic studies show that the reaction may proceed through a radical process in which benzoyl aldehyde oxime is not only a substrate, but also an ancillary ligand to support iron salt in the promotion of the transformation.