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Asymmetric Allylic Alkylation of Alkanoic‐Acid Ester Enolates
Author(s) -
Visse Robin,
Möllemann MartinAlexander,
Braun Manfred
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201900822
Subject(s) - chemistry , stereocenter , tsuji–trost reaction , allylic rearrangement , alkylation , lithium (medication) , palladium , organic chemistry , stereochemistry , enantioselective synthesis , catalysis , medicine , endocrinology
A protocol for the direct palladium‐catalyzed asymmetric allylic alkylation of simple alkanoic‐acid esters through their lithium enolates has been developed. The method permits to create stereogenic centers in the homo‐allylic or allylic position. The configuration of the allylation products has been elucidated.