Convergent Synthesis of the Hexasaccharide Repeating Unit of the  O ‐Antigenic OPS of  Escherichia coli  O133 | Zendy

Mitra Ankita | Zendy; Mukhopadhyay Balaram | Zendy

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Convergent Synthesis of the Hexasaccharide Repeating Unit of the O ‐Antigenic OPS of Escherichia coli O133

Author(s) -

Mitra Ankita,

Mukhopadhyay Balaram

Publication year - 2019

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201900815

Subject(s) - chemistry , moiety , monosaccharide , escherichia coli , stereoselectivity , uronic acid , stereochemistry , glycosylation , protecting group , convergent synthesis , catalysis , polysaccharide , biochemistry , organic chemistry , gene , alkyl

Synthesis of the hexasaccharide repeating unit of the O‐antigen from E. coli O133 has been accomplished with rational protecting group manipulations on commercially available monosaccharides and stereoselective glycosylations through a convergent protocol. A late stage TEMPO mediated oxidation is used to install the required uronic acid moiety. Chloroacetate group is used extensively as a temporary protecting group.

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