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C4‐Selective Synthesis of Vinyl Thiocyanates and Selenocyanates Through 3,4‐Dihalo‐2(5 H )‐furanones
Author(s) -
Wu HanQing,
Yang Kai,
Luo ShiHe,
Wu XinYan,
Wang Neng,
Chen SiHong,
Wang ZhaoYang
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201900749
Subject(s) - chemistry , sodium bicarbonate , catalysis , organic chemistry , thiocyanate , combinatorial chemistry
In the absence of a metal catalyst and under the promotion of sodium bicarbonate, an eco‐friendly and practical protocol for the synthesis of vinyl thiocyanate derivatives through the reaction of 3,4‐dihalo‐2(5 H )‐furanones with KSCN at room temperature has been developed. This method has a broad substrate scope and is suitable for gram‐scale synthesis (up to 5 g). Importantly, it can also be used to synthesize vinyl selenocyanate derivatives.