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Site‐Specific Synthesis of β‐Fluorinated γ‐Butyrolactams via Decarboxylative Fluorination of β‐Carboxyl‐γ‐Butyrolactams
Author(s) -
Phaenok Supasorn,
Pohmakotr Manat,
Kuhakarn Chutima,
Reutrakul Vichai,
Soorukram Darunee
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201900685
Subject(s) - selectfluor , chemistry , fluorine , organic chemistry , halogenation , combinatorial chemistry , organic synthesis , catalysis
Monofluorinated cyclic nitrogen‐containing compounds are synthetically useful scaffolds in organic synthesis and medicinal applications. In this report, AgNO 3 mediated decarboxylative fluorination of β‐carboxyl‐γ‐butyrolactams using Selectfluor® as a fluorine source was described to achieve a site‐specific synthesis of β‐fluorinated γ‐butyrolactams.