Site‐Specific Synthesis of β‐Fluorinated γ‐Butyrolactams via Decarboxylative Fluorination of β‐Carboxyl‐γ‐Butyrolactams | Zendy

Phaenok Supasorn | Zendy; Pohmakotr Manat | Zendy; Kuhakarn Chutima | Zendy; Reutrakul Vichai | Zendy; Soorukram Darunee | Zendy

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Site‐Specific Synthesis of β‐Fluorinated γ‐Butyrolactams via Decarboxylative Fluorination of β‐Carboxyl‐γ‐Butyrolactams

Author(s) -

Phaenok Supasorn,

Pohmakotr Manat,

Kuhakarn Chutima,

Reutrakul Vichai,

Soorukram Darunee

Publication year - 2019

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201900685

Subject(s) - selectfluor , chemistry , fluorine , organic chemistry , halogenation , combinatorial chemistry , organic synthesis , catalysis

Monofluorinated cyclic nitrogen‐containing compounds are synthetically useful scaffolds in organic synthesis and medicinal applications. In this report, AgNO 3 mediated decarboxylative fluorination of β‐carboxyl‐γ‐butyrolactams using Selectfluor® as a fluorine source was described to achieve a site‐specific synthesis of β‐fluorinated γ‐butyrolactams.

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