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Cu‐Mediated Synthesis of Indolines and Dihydroisoquinolinones through Arylperfluoroalkylation of Unactivated Alkenes
Author(s) -
Li Dandan,
Wang Yan,
Jia Zhenzhen,
Ou Zhaocheng,
Dong Yongrui,
Lv Cunjie,
Fu Guangbin,
Liang Deqiang
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201900680
Subject(s) - chemistry , reagent , functional group , combinatorial chemistry , acceptor , organic chemistry , medicinal chemistry , physics , condensed matter physics , polymer
The copper‐mediated fluroalkylation/cyclization of N ‐allyl anilines has been described using fluoroalkyl iodides as fluoroalkylation reagents for the first time. The reaction provides an efficient and direct access to 3‐fluoroalkyl indolines in moderate to good yields with unactivated double bonds as the radical acceptor. This protocol combines a simple experimental procedure with low‐costing fluoroalkylated sources and excellent functional group tolerance.