Potassium  tert ‐Butoxide Prompted Highly Efficient Transamidation and Its Coordination Radical Mechanism | Zendy

Tan Zhiyong | Zendy; Li Zhenhua | Zendy; Ma Yao | Zendy; Qin Jinjing | Zendy; Yu Chuanming | Zendy

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Potassium tert ‐Butoxide Prompted Highly Efficient Transamidation and Its Coordination Radical Mechanism

Author(s) -

Tan Zhiyong,

Li Zhenhua,

Ma Yao,

Qin Jinjing,

Yu Chuanming

Publication year - 2019

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201900666

Subject(s) - chemistry , substrate (aquarium) , coordination complex , combinatorial chemistry , mechanism (biology) , potassium , organic chemistry , metal , philosophy , oceanography , epistemology , geology

A simple and highly efficient protocol was developed for the transamidation of N , N ‐disubstituted amides with primary amines in the presence of t BuOK, affording desired products in good to excellent yields. This reaction proceeded under nitrogen atmosphere and featured extensive substrate tolerance. Experimental investigation suggested that a coordination radical process enhanced this transformation.

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