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Potassium tert ‐Butoxide Prompted Highly Efficient Transamidation and Its Coordination Radical Mechanism
Author(s) -
Tan Zhiyong,
Li Zhenhua,
Ma Yao,
Qin Jinjing,
Yu Chuanming
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201900666
Subject(s) - chemistry , substrate (aquarium) , coordination complex , combinatorial chemistry , mechanism (biology) , potassium , organic chemistry , metal , philosophy , oceanography , epistemology , geology
A simple and highly efficient protocol was developed for the transamidation of N , N ‐disubstituted amides with primary amines in the presence of t BuOK, affording desired products in good to excellent yields. This reaction proceeded under nitrogen atmosphere and featured extensive substrate tolerance. Experimental investigation suggested that a coordination radical process enhanced this transformation.