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Photoredox Catalysis for Silyl‐Mediated C–H Alkylation of Heterocycles with Non‐Activated Alkyl Bromides
Author(s) -
Perkins James J.,
Schubert Jeffrey W.,
Streckfuss Eric C.,
Balsells Jaume,
ElMarrouni Abdellatif
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201900611
Subject(s) - chemistry , photoredox catalysis , alkylation , alkyl , silylation , catalysis , combinatorial chemistry , surface modification , organic chemistry , photochemistry , photocatalysis
The development of a Minisci reaction of electron‐deficient heteroarenes with non‐activated alkyl bromides under visible‐light photoredox catalysis is disclosed. Optimization of the reaction led to identification of mild, general, and practical reaction conditions compatible with sensitive functional groups. The scope of this transformation allowed late‐stage functionalization of pharmaceutical products containing electron‐deficient heteroarenes in a parallel fashion.