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Base‐Catalyzed 1,6‐Hydrophosphonylation of p ‐Quinone Methides with Diphenylphosphane Oxide/Phosphites
Author(s) -
Zhang Bin,
Liu Lu,
Mao Shukuan,
Zhou MingDong,
Wang He,
Li Lei
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201900606
Subject(s) - chemistry , phosphonate , catalysis , base (topology) , scope (computer science) , conjugated system , substrate (aquarium) , oxide , functional group , combinatorial chemistry , organic chemistry , metal , reaction conditions , mathematical analysis , oceanography , mathematics , computer science , programming language , geology , polymer
A novel base‐catalyzed 1,6‐conjugated addition of p ‐QMs with diphenylphosphane oxide/phosphites has been developed. This reaction provides a highly efficient strategy for the construction of diarylmethyl phosphonate compounds in moderate to excellent yields with a broad substrate scope and good functional group tolerance under mild and metal‐free conditions. Moreover, the reaction can be carried out on a gram scale, which opens up the possibility for practical applications.
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