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Oxidative Thioesterification of Alkenes Mediated by 1,3‐Dibromo‐5,5‐dimethylhydantoin and DMSO for the Synthesis of α‐Ketothioesters
Author(s) -
Hua Jiawei,
Xu Jiaqi,
Xu Jia,
Zhou Bochao,
Zhang Dong,
Yang Zhao,
Fang Zheng,
Guo Kai
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201900585
Subject(s) - chemistry , oxidative phosphorylation , bromide , organic chemistry , oxidative addition , scope (computer science) , substrate (aquarium) , combinatorial chemistry , medicinal chemistry , biochemistry , catalysis , oceanography , geology , computer science , programming language
A simple and mild approach for the synthesis of α‐ketothioesters via 1,3‐Dibromo‐5,5‐dimethylhydantoin (DBH)/DMSO mediated oxidative thioesterification of alkenes has been developed. Various of α‐ketothioesters products were produced in moderate to good yields under metal‐free conditions. And this method features readily available starting materials and broad substrate scope. Moreover, a plausible mechanism was proposed based on the methyl bromide captured experiment.