One‐Pot Synthesis of 3‐(2‐Fluoroalkenyl)indoles | Zendy

Aldoshin Alexander S. | Zendy; Tabolin Andrey A. | Zendy; Ioffe Sema L. | Zendy; Nenajdenko Valentine G. | Zendy

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One‐Pot Synthesis of 3‐(2‐Fluoroalkenyl)indoles

Author(s) -

Aldoshin Alexander S.,

Tabolin Andrey A.,

Ioffe Sema L.,

Nenajdenko Valentine G.

Publication year - 2019

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201900573

Subject(s) - chemistry , yield (engineering) , catalysis , michael reaction , organic chemistry , base (topology) , combinatorial chemistry , mathematical analysis , materials science , mathematics , metallurgy

An unprecedented one‐pot synthesis of 3‐(fluoroalkenyl)indoles was developed. This process involves a catalyst‐free Michael addition of β‐fluoro‐β‐nitrostyrenes to indoles in neat followed by elimination of HNO 2 using DBU as a base. The effectiveness of this approach was demonstrated through the preparation of variety of target products in up to 75 % isolated yield.

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